Human fibroblasts express five tropomyosin‐like proteins, three of which have been shown to be structurally related to each other and to tropomyoins from muscle sources. These cytoskeletal tropomyosins are transcribed from three separate, non‐overlapping structural genes. However, each of these structural genes can also produce additional tropomyosin isoforms by a tissue‐specific alternative mRNA splicing mechanism.

Experts often communicate probabilities verbally (e.g., unlikely) rather than numerically (e.g., 25% chance). Although criticism has focused on the vagueness of verbal probabilities, less attention has been given to the potential unintended, biasing effects of verbal probabilities in communicating probabilities to decision-makers. In four experiments (Ns = 201, 439, 435, 696), we showed that probability format (i.e., verbal vs. numeric) influenced participants’ inferences and decisions following a hypothetical financial expert’s forecast. We observed a format effect for low probability forecasts: verbal (...) probabilities were interpreted more pessimistically than numeric equivalents. We attributed the difference to directionality, a linguistic property that biases attention toward an outcome. In the high-probability conditions, the directionality of verbal and numeric probabilities aligned (both were positive), whereas they differed in the low-probability conditions (verbal probabilities were more negative). Participants inferred recommendations congruent with the communicated direction and these inferences mediated the effect of probability format on decisions. (shrink)

BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.MethodsIn a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication (...) in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-group differences in the proportion of manuscripts meeting all ARRIVE guideline checklist subitems.ResultsWe randomised 1689 manuscripts (control: n = 844, intervention: n = 845), of which 1269 were sent for peer review and 762 (control: n = 340; intervention: n = 332) accepted for publication. No manuscript in either group achieved full compliance with the ARRIVE checklist. Details of animal husbandry (ARRIVE subitem 9b) was the only subitem to show improvements in reporting, with the proportion of compliant manuscripts rising from 52.1 to 74.1% (X2 = 34.0, df = 1, p = 2.1 × 10−7) in the control and intervention groups, respectively.ConclusionsThese results suggest that altering the editorial process to include requests for a completed ARRIVE checklist is not enough to improve compliance with the ARRIVE guidelines. Other approaches, such as more stringent editorial policies or a targeted approach on key quality items, may promote improvements in reporting. (shrink)

ABSTRACTAnxious individuals report disproportionately negative expectations concerning the future, termed the negative expectancy bias. In contrast, ageing is associated with an inflated expectancy for positive future events. A recent study [Steinman, S. A., Smyth, F. L., Bucks, R. S., MacLeod, C., & Teachman, B. A.. Anxiety-linked expectancy bias across the adult lifespan. Cognition and Emotion, 27, 345–355. doi:10.1080/02699931.2012.711743] found using an interpretation bias task, a negative expectancy bias in young adults and positive expectancy bias in older adults with high (...) trait anxiety. Extending this, the current study examined expectancy bias for positive, negative and ambiguously emotionally toned information in younger and older adults with clinical levels of depression and anxiety to community control groups, thus allowing examination of both disorder status and age on biases. Clinical participants reported a pervasive tendency to expect negative events relative to positive regardless o... (shrink)

A laboratory-testable, solid-state Maxwell demon is proposed that utilizes the electric field energy of an open-gap p-n junction. Numerical results from a commercial semiconductor device simulator (Silvaco International–Atlas) verify primary results from a 1-D analytic model. Present day fabrication techniques appear adequate for laboratory tests of principle.

First published in 1976, the _Dictionary of Philosophy_ has established itself as the best available text of its kind, explaining often unfamiliar, complicated and diverse terminology. Thoroughly revised and expanded, this fourth edition provides authoritative and rigorous definitions of a broad range of philosophical concepts. Concentrating on the Western philosophical tradition,_ The Routledge Dictionary of Philosophy_ offers an illuminating and informed introduction to the central issues, ideas and perspectives in core fields such as metaphysics, epistemology, and logic. It includes concise (...) biographical entries for more than one hundred major philosophers, from Plato and Aristotle through to contemporary figures such as Dummett, McDowell, Parfit and Singer. All major entries are followed by helpful suggestions for further reading, including web links, and contain extensive cross-referencing to aid access and comprehension. This edition also features a brand new guide to the most useful philosophy sites on the internet. _The Routledge Dictionary of Philosophy_ is an invaluable and up-to-date resource for all students of philosophy. (shrink)

On the Athenian disaster at Aegospotami the reaction, suppressed half a dozen years before, against the régime responsible for the war and its calamitous results sprang up again with double force. The capture of the fleet, the loss of the empire, which had been a useful buffer between the selfish interests of the wealthier citizens and the predatory appetites of the proletariate, the bankruptcy of the treasury, the discredit of the whole democratic system, the grim privations of the blockade, and (...) the imminent return of the exiles eager for power and vengeance, all portended the speedy downfall of the constitution, should the victorious enemy leave it standing. Yet the progress of the revolution was slower than might have been expected. In fact the oligarchs were at first crippled by the absence of their banished chiefs, andthroughout they had to reckon not only with a people which had long enjoyed liberty and empireand with a democratic administration already in office, but also with the middle party, disgusted indeed with the existing form of government but unwilling to substitute for it the rule ofa narrow privileged class, and led by a statesman of great ability and experience. (shrink)

An introductory work on the various school of Indian philosophy.

Wilhelm Bousset, a leading member of the religionsgeschichtliche school and author of a seminal work on early Christology, Kyrios Christos, is typically regarded by reviewers of his work as a classic nineteenth-century liberal who sought a secure foundation for faith in the historical Jesus. However, this view of Bousset fails to appreciate the significant development of his theological perspective on the relationship between faith and history, a perspective that underwent a profound shift due to the influence of the English historian (...) Thomas Carlyle and the Kantian philosopher Jakob Friedrich Fries. It is the influence of these two figures that enables Bousset to justify a full-scale flight from history and to seek faith's foundation elsewhere, in the poetic symbol of Jesus Christ. The resulting solution to the problem of faith and history represents a unique and compelling alternative to the solutions of the leading theologians and New Testament scholars of the early twentieth century. (shrink)

When Pythodorus in 411 B.C. moved in the Athenian Assembly his decree that Commissioners should be elected to draft measures for the security of the State, Cleitophon added a rider instructing the Commissioners προσαναξητσαι κα τος πατρονς νμονς ος κλειδθνης θηκεν τε καθδτη τν δημοκραταν, πως ν κοσαντες κα τοτων βολεσωντααι τ ριστον. The instruction appears to have struck Aristotle as paradoxical and inept, for he has appended an explanation of Cleitophon's reasons which is also a criticism: ς ο δημοτικν (...) λλ παραπλησαν οσαν τν Kλεισθνους πολιτεαν τ Σλωνος. Indeed one would never imagine that the constitution of Cleisthenes as described by Aristotle could have been seriously suggested as a model or a repertory of precedents for legislators intent, like Cleitophon's friends, on restoring the πτριος πολιτεα, which it obviously disestablished; and the conjunction of τοĐς πατρουσ with τε καθστη τν δημοκραταν might seem to make the proposal a challenge or a mockery. Aristotle had already given his opinion that by Cleisthenes' innovations δημοτικωτρα πολĐ τς Σλωνος γνετο πολιτεα He recognized democratic features in Solon's laws, but they lay in the redress of social wrongs or in the method of administering justice rather than in the organization of the government; he regarded Solon's political changes, not as the establishment of democracy proper, but as a reform, conservative rather than revolutionary, of existent institutions. His comment on the rider implies that he would not have corrected Cleitophon if he had referred the Commissioners to Solon's ancestral laws, but to refer them to Cleisthenes' must, he thought, be ignorance, irony, or idiosyncrasy. (shrink)

Resumo Palavras-chave Keywords : Children’s literature. Music. Pedagogical practice : This article’s main purpose is to present a few possibilities of work with activities that involve pieces of children’s literature and music in the perspective of Children’s Education and first years of Primary School. As theoretical support, the paper presents several studies from authors such as Brito (2003), Ponso (2008), Souza (2006), Torres and Gallicchio (2004), among others who suggest developing activities of sound exploration through audition/appreciation and improvise/ sound editing (...) from some texts and books of children’s literature. A conclusion has been reached that the proposal of activities transforming words in music enables readers to experiment different sounds to compose the soundtrack of stories. Besides, when selecting a diversified repertoire with several texts, possibilities are created to the students to tell, recount and sing varied stories, allowing, thus, the entrance of different social voices. : Literatura Infantil. Música. Prática pedagógica. : O objetivo maior deste artigo é o de apresentar algumas possibilidades de trabalho com atividades que envolvam obras de literatura infantil e músicas, na perspectiva da Educação Infantil e Séries Iniciais do Ensino Fundamental. Como suporte teórico, o trabalho apresenta diversos estudos de autores, tais como Brito (2003), Ponso (2008), Souza (2006),Torres e Gallicchio (2004) entre outros, que sugerem desenvolver atividades de exploração sonora através da audição/ apreciação e improvisação/sonorização a partir de alguns textos e de livros de literatura infantil. Constatou-se que a proposta de atividades, transformando palavras em músicas, possibilita interpelar os leitores a experimentarem diferentes sons para compor a trilha sonora de histórias. Além disso, ao selecionar um repertório diversificado com vários textos, criam-se possibilidades aos alunos para contarem, recontarem e cantarem variadas histórias, permitindo, dessa maneira, a entrada de diferentes vozes sociais. (shrink)

Organ availability for transplantation has become an increasingly complex and difficult question in health economics and ethical practice. Advances in technology have seen prolonged life expectancy, and the global push for organs creates an ever-expanding gap between supply and demand, and a significant cost in bridging that gap. This article will examine the ethical implications for the nursing profession in regard to the procurement of organs from an impoverished seller’s market, also known as ‘Transplant Tourism’. This ethical dilemma concerns itself (...) with resource allocation, informed consent and the concepts of egalitarianism and libertarianism. Transplant Tourism is an unacceptable trespass against human dignity and rights from both a nursing and collective viewpoint. Currently, the Australian Nursing and Midwifery Council, the Royal college of Nursing Australia, The Royal College of Nursing (UK) and the American Nurses Association do not have position statements on transplant tourism, and this diminishes us as a force for change. It diminishes our role as advocates for the most marginalised in our world to have access to care and to choice and excludes us from a very contemporary real debate about the mismatch of organ demand and supply in our own communities. As a profession, we must have a voice in health policy and human rights, and according to our Code of Ethics in Australia and around the world, act to promote and protect the fundamental human right to healthcare and dignity. (shrink)